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Altering Perceptions on Psychedelics Harvard Medicine magazine Wittmann et al. carried out a study to elucidate the role of the serotonin system in time perception and temporal behavior. Theirs was the first study to systematically assess the effect of psilocybin on timing performance on standardized measures of temporal processing. They used a placebo-controlled, double-blind design in 12 healthy volunteers, administering placebo, a medium psilocybin dose of 115 μg/kg, or a high psilocybin dose of 250 μg/kg. The standardized measures of temporal processing included the temporal reproduction, sensorimotor synchronization, and tapping speed . Using double in situ hybridization, Santana et al. performed a quantitative study of the expression of α1A, α1B, and α1D adrenergic receptors in pyramidal vesicular glutamate transporter 1–positive and GABAergic (GAD65/67–positive) cells of rat PFC. Given the common signaling pathways shared by 5-HT2A and α1 adrenergic receptors, they examined th